Biologic response modifiers: Indications, implications, and insights.

作者: Benjamin P. Davis , Zuhair K. Ballas

DOI: 10.1016/J.JACI.2017.02.013

关键词:

摘要: The field of biologic immune modulators is currently mushrooming at a dizzying pace. Although most these biologics are tested and approved for one or few indications, their unanticipated side effects off-label use have contributed significantly to our understanding basic mechanisms, the involvement cytokines in several apparently nonimmunologic diseases, importance compartmentalized responses. In this review we attempt give bird's-eye view major highlight insights implications derived from secondary adverse reactions.

参考文章(125)
Joseph R. Berger, Igor J. Koralnik, Progressive multifocal leukoencephalopathy and natalizumab - : Unforeseen consequences The New England Journal of Medicine. ,vol. 353, pp. 414- 416 ,(2005) , 10.1056/NEJME058122
Ian D Pavord, Stephanie Korn, Peter Howarth, Eugene R Bleecker, Roland Buhl, Oliver N Keene, Hector Ortega, Pascal Chanez, Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. The Lancet. ,vol. 380, pp. 651- 659 ,(2012) , 10.1016/S0140-6736(12)60988-X
Oluwabunmi Y. Saliu, Carolina Sofer, Dana S. Stein, Stephan K. Schwander, Robert S. Wallis, Tumor-Necrosis-Factor Blockers: Differential Effects on Mycobacterial Immunity The Journal of Infectious Diseases. ,vol. 194, pp. 486- 492 ,(2006) , 10.1086/505430
F. Stephen Hodi, Steven J. O'Day, David F. McDermott, Robert W. Weber, Jeffrey A. Sosman, John B. Haanen, Rene Gonzalez, Caroline Robert, Dirk Schadendorf, Jessica C. Hassel, Wallace Akerley, Alfons J.M. van den Eertwegh, Jose Lutzky, Paul Lorigan, Julia M. Vaubel, Gerald P. Linette, David Hogg, Christian H. Ottensmeier, Celeste Lebbé, Christian Peschel, Ian Quirt, Joseph I. Clark, Jedd D. Wolchok, Jeffrey S. Weber, Jason Tian, Michael J. Yellin, Geoffrey M. Nichol, Axel Hoos, Walter J. Urba, Improved Survival with Ipilimumab in Patients with Metastatic Melanoma. The New England Journal of Medicine. ,vol. 363, pp. 711- 723 ,(2010) , 10.1056/NEJMOA1003466
A. J. Fine, A. Sorbello, C. Kortepeter, L. Scarazzini, Central Nervous System Herpes Simplex and Varicella-Zoster Virus Infections in Natalizumab-Treated Patients Clinical Infectious Diseases. ,vol. 57, pp. 849- 852 ,(2013) , 10.1093/CID/CIT376
Joel M. Kremer, Harry K. Genant, Larry W. Moreland, Anthony S. Russell, Paul Emery, Carlos Abud-Mendoza, Jacek Szechinski, Tracy Li, Zhiyu Ge, Jean-Claude Becker, Rene Westhovens, Effects of abatacept in patients with methotrexate-resistant active rheumatoid arthritis: a randomized trial. Annals of Internal Medicine. ,vol. 144, pp. 865- 876 ,(2006) , 10.7326/0003-4819-144-12-200606200-00003
Iain B McInnes, Philip J Mease, Bruce Kirkham, Arthur Kavanaugh, Christopher T Ritchlin, Proton Rahman, Désirée van der Heijde, Robert Landewé, Philip G Conaghan, Alice B Gottlieb, Hanno Richards, Luminita Pricop, Gregory Ligozio, Manmath Patekar, Shephard Mpofu, Secukinumab, a human anti-interleukin-17A monoclonal antibody, in patients with psoriatic arthritis (FUTURE 2): a randomised, double-blind, placebo-controlled, phase 3 trial The Lancet. ,vol. 386, pp. 1137- 1146 ,(2015) , 10.1016/S0140-6736(15)61134-5
D G Maloney, A J Grillo-López, D J Bodkin, C A White, T M Liles, I Royston, C Varns, J Rosenberg, R Levy, IDEC-C2B8: results of a phase I multiple-dose trial in patients with relapsed non-Hodgkin's lymphoma. Journal of Clinical Oncology. ,vol. 15, pp. 3266- 3274 ,(1997) , 10.1200/JCO.1997.15.10.3266
Lone Schejbel, Dag Fadnes, Henrik Permin, Knut Tore Lappegård, Peter Garred, Tom Eirik Mollnes, Primary complement C5 deficiencies - molecular characterization and clinical review of two families. Immunobiology. ,vol. 218, pp. 1304- 1310 ,(2013) , 10.1016/J.IMBIO.2013.04.021
Joerg-Patrick Stübgen, Tumor necrosis factor-α antagonists and neuropathy Muscle & Nerve. ,vol. 37, pp. 281- 292 ,(2008) , 10.1002/MUS.20924