Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial.
作者： Ian D Pavord , Stephanie Korn , Peter Howarth , Eugene R Bleecker , Roland Buhl
DOI: 10.1016/S0140-6736(12)60988-X
关键词:
摘要: … airway inflammation with mepolizumab—a monoclonal … associated with the response to mepolizumab. METHODS: We … one of three doses of intravenous mepolizumab (75 mg, 250 mg…
sci-hub.se 参考文章(28)
Romain A. Pauwels, GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION アレルギー. ,vol. 45, pp. 792- ,(1996)
Mona Bafadhel, Susan McKenna, Sarah Terry, Vijay Mistry, Carlene Reid, Pranabashis Haldar, Margaret McCormick, Koirobi Haldar, Tatiana Kebadze, Annelyse Duvoix, Kerstin Lindblad, Hemu Patel, Paul Rugman, Paul Dodson, Martin Jenkins, Michael Saunders, Paul Newbold, Ruth H. Green, Per Venge, David A. Lomas, Michael R. Barer, Sebastian L. Johnston, Ian D. Pavord, Christopher E. Brightling, Acute Exacerbations of Chronic Obstructive Pulmonary Disease American Journal of Respiratory and Critical Care Medicine. ,vol. 184, pp. 662- 671 ,(2011) , 10.1164/RCCM.201104-0597OC
Micaela Romagnoli, Gaetano Caramori, Fausto Braccioni, Franco Ravenna, Esther Barreiro, NM Siafakas, Antonio M Vignola, Pascal Chanez, Leonardo M Fabbri, Alberto Papi, ENFUMOSA Study Group, None, Near-fatal asthma phenotype in the ENFUMOSA Cohort Clinical & Experimental Allergy. ,vol. 37, pp. 552- 557 ,(2007) , 10.1111/J.1365-2222.2007.02683.X
Margaret J Leckie, Anneke ten Brinke, Jamey Khan, Zuzana Diamant, Brian J O'connor, Christine M Walls, Ashwini K Mathur, Hugh C Cowley, K Fan Chung, Ratko Djukanovic, Trevor T Hansel, Stephen T Holgate, Peter J Sterk, Peter J Barnes, None, Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response The Lancet. ,vol. 356, pp. 2144- 2148 ,(2000) , 10.1016/S0140-6736(00)03496-6
Pranabashis Haldar, Christopher E. Brightling, Beverley Hargadon, Sumit Gupta, William Monteiro, Ana Sousa, Richard P. Marshall, Peter Bradding, Ruth H. Green, Andrew J. Wardlaw, Ian D. Pavord, Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma The New England Journal of Medicine. ,vol. 360, pp. 973- 984 ,(2009) , 10.1056/NEJMOA0808991
Patrick Flood-Page, Cheri Swenson, Isidore Faiferman, John Matthews, Michael Williams, Lesley Brannick, Douglas Robinson, Sally Wenzel, William Busse, Trevor T. Hansel, Neil C. Barnes, , A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma. American Journal of Respiratory and Critical Care Medicine. ,vol. 176, pp. 1062- 1071 ,(2007) , 10.1164/RCCM.200701-085OC
Elizabeth F. Juniper, Gordon H. Guyatt, Penelope J. Ferrie, Lauren E. Griffith, Measuring Quality of Life in Asthma The American review of respiratory disease. ,vol. 147, pp. 832- 838 ,(1993) , 10.1164/AJRCCM/147.4.832
Pascal Chanez, Sally E. Wenzel, Gary P. Anderson, Josep M. Anto, Elisabeth H. Bel, Louis-Philippe Boulet, Christopher E. Brightling, William W. Busse, Mario Castro, Babro Dahlen, Sven Erik Dahlen, Leo M. Fabbri, Stephen T. Holgate, Marc Humbert, Mina Gaga, Guy F. Joos, Bruce Levy, Klaus F. Rabe, Peter J. Sterk, Susan J. Wilson, Isabelle Vachier, Severe asthma in adults: what are the important questions? The Journal of Allergy and Clinical Immunology. ,vol. 119, pp. 1337- 1348 ,(2007) , 10.1016/J.JACI.2006.11.702
Elizabeth F. Juniper, Klas Svensson, Ann-Christin Mörk, Elisabeth Ståhl, Measurement properties and interpretation of three shortened versions of the asthma control questionnaire Respiratory Medicine. ,vol. 99, pp. 553- 558 ,(2005) , 10.1016/J.RMED.2004.10.008
Parameswaran Nair, Marcia M.M. Pizzichini, Melanie Kjarsgaard, Mark D. Inman, Ann Efthimiadis, Emilio Pizzichini, Frederick E. Hargreave, Paul M. O'Byrne, Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia The New England Journal of Medicine. ,vol. 360, pp. 985- 993 ,(2009) , 10.1056/NEJMOA0805435