Angiogenesis in the embryonic CNS: a new twist on an old tale.

摘要: The central nervous system (CNS) acquires its vasculature by angiogenesis, a process consisting of proliferation endothelial cells in existing blood vessels or vascular plexuses, and leading to formation new vessels. Angiogenesis begins early CNS development continues throughout life. Prevailing notions depict angiogenesis as passive driven primarily demands for oxygen other nutrients the growing neuronal populations. Thus, although develops concomitant with identities, which emerge under influence compartment-specific cell autonomous factors, patterning signals are not considered instruct development. We have challenged this prevailing notion showing that mouse telencephalon progresses an orderly, ventral-to-dorsal gradient regulated cell-autonomous manner homeobox transcription factors. These same factors confer compa...