MicroRNA Implications across Neurodevelopment and Neuropathology

摘要: MicroRNAs (miRNAs) have rapidly emerged as biologically important mediators of posttranscriptional and epigenetic regulation in both plants animals. miRNAs function through a variety mechanisms including mRNA degradation translational repression; additionally, may guide gene expression by serving transcription factors. are highly expressed human brain. Tissue cell type-specific enrichments certain within the nervous system argue for biological significance during neurodevelopmental stages. On other hand, large number studies reported links between alterations miRNA homeostasis pathologic conditions such cancer, heart diseases, neurodegeneration. Thus, profiles distinct or aberrant signatures most recently surged one fascinating interests current biology. Here, recent insights into involvement biology occurrence neuropathological disorders reviewed discussed.