Methods and systems for multi-antibody therapies
作者： Charles B. Shoemaker , Jean Mukherjee
DOI:
关键词:
摘要: The present invention relates to methods and systems for administering antibody therapeutic agents. include one or more (e.g., two three) binding agents, wherein each of the agents has a region that is specific portion disease agent copies tag. can be portions same different tag an anti-tag antibody, tag, have immunoglobulin IgA, IgD, IgE, IgG, IgM.). Disease bacterial proteins, viral cancer cells, proteins toxins produced therefrom. In particular, includes are neurotoxins cause botulism.
google.ca 参考文章(5)
Dana Ault-Riche, Ronald Levy, Design of therapeutics and therapeutics ,(2005)
Sean B. Carroll, Antivenoms and methods for making antivenoms ,(1990)
Judith A. Abraham, John C. Fiddes, Richard L. Mitchell, Edmund G. Tischer, Production of vascular endothelial cell growth factor ,(1990)
A. Nowakowski, C. Wang, D. B. Powers, P. Amersdorfer, T. J. Smith, V. A. Montgomery, R. Sheridan, R. Blake, L. A. Smith, J. D. Marks, Potent neutralization of botulinum neurotoxin by recombinant oligoclonal antibody. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 11346- 11350 ,(2002) , 10.1073/PNAS.172229899
M. Cohn, The immune system A look from a distance Frontiers in Bioscience. ,vol. 1, pp. d318- 323 ,(1996) , 10.2741/A134