Universal anti-tag chimeric antigen receptor-expressing t cells and methods of treating cancer
作者： Koji Tamada , Eduardo Davila
DOI:
关键词: Antigen presentation 、 Cytotoxic T cell 、 IL-2 receptor 、 T cell 、 Streptamer 、 Biology 、 Interleukin 21 、 Cancer research 、 Antigen 、 Antigen-presenting cell 、 Molecular biology
摘要: The present invention provides a universal, yet adaptable, anti-tag chimeric antigen receptor (AT-CAR) system which T cells with the ability and specificity to recognize kill target cells, such as tumor that have been marked by tagged antibodies. As an example, αFITC-CAR-expressing developed specifically various human cancer when those are bound cancer-reactive FITC-labeled activation of is shown induce efficient lysis, cell proliferation, cytokine/chemokine production. can be used treating subjects having cancer.
lens.org参考文章(64)
Dale Gl, Gaddy P, Pikul Fj, Antibodies against biotinylated proteins are present in normal human serum. Journal of Laboratory and Clinical Medicine. ,vol. 123, pp. 365- 371 ,(1994)
R. A. Reisfeld, S. Sell, Monoclonal antibodies and cancer therapy UCLA symposium on molecular and cellular biology. Annual meeting. 14. pp. 33- 74 ,(1985)
Kristina Ellwanger, Uwe Reusch, Ivica Fucek, Michael Weichel, Erich Rajkovic, Martin Treder, Palmitic acid conjugation of a protein antigen enhances major histocompatibility complex class II-restricted presentation to T cells. Immunology. ,vol. 76, pp. 593- 598 ,(2016) , 10.1158/1538-7445.AM2016-593
John B Zabriskie, None, Essential Clinical Immunology ,(2009)
G S Ogg, P R Dunbar, V Cerundolo, A J McMichael, N R Lemoine, P Savage, Sensitization of tumour cells to lysis by virus-specific CTL using antibody-targeted MHC class I/peptide complexes. British Journal of Cancer. ,vol. 82, pp. 1058- 1062 ,(2000) , 10.1054/BJOC.1999.1042
John C. Kendrew, Eleanor Lawrence, The encyclopedia of molecular biology Blackwell Science. ,(1995)
Seppo Yla-Herttuala, Varpu Marjomaki, Markku Kulomaa, Pauliina Lehtolainen, Kari Airenne, Biotin-binding receptor molecules ,(1999)
Charles B. Shoemaker, Jean Mukherjee, Methods and systems for multi-antibody therapies ,(2010)
Laurence Cooper, Michael Jensen, Mammalian antigen-presenting T cells and bi-specific T cells ,(2004)
Lawrence G Lum, Archana Thakur, Cancer therapy with bispecific antibodies: Clinical experience. Current Opinion in Molecular Therapeutics. ,vol. 12, pp. 340- 349 ,(2010)