Hyperoxic Regulation of Lung Heme Oxygenase in Neonatal Rats
作者： Phyllis A Dennery , Pamela A Rodgers , Melissa A Lum , Blair C Jennings , Vida Shokoohi
DOI: 10.1203/00006450-199612000-00007
关键词:
摘要: In the neonatal lung, hyperoxic exposure is associated with induction of various genes and critical antioxidants. Heme oxygenase, specifically HO-1 isoenzyme, regulated in oxidant stress may also serve to limit oxidative damage. However, it not known whether lung hyperoxia and, if so, what type regulation occurs. Therefore, we attempted answer these questions using newly born(< 12 h) Wistar rats exposed for 3 d. Neonatal rat lungs were evaluated daily total HO activity, immunore-active protein, steady state levels mRNA compared air-exposed controls. rats, noted an increased activity after d exposure. Additionally, evaluation immunoprecipitation protein suggested that contributed most increase observed hyperoxia. Nonetheless, did see a significant difference immunoreactive exposure, although so on 2. Also, contrast previous reports, detect any differences day air. We therefore conclude speculate occurs by posttranscriptional mechanisms, at least within first days
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