Effects of vitamin D supplementation on symptoms of depression in overweight and obese subjects: randomized double blind trial

摘要: . Objectives.  The objective of the present study was to examine cross-sectional relation between serum 25-hydoxyvitamin D [25-(OH) D] levels and depression in overweight obese subjects assess effect vitamin supplementation on depressive symptoms. Design.  Cross-sectional randomized double blind controlled trial 20.000 or 40.000 IU per week versus placebo for 1 year. Setting.  A total 441 (body mass index 28–47 kg m−2, 159 men 282 women, aged 21–70 years) recruited by advertisements from out-patient clinic at University Hospital North Norway. Main outcome measures.  Beck Depression Inventory (BDI) score with subscales 1–13 14–21. Results.  Subjects 25(OH)D <40 nmol L−1 scored significantly higher (more traits) than those ≥40 nmol L−1 BDI [6.0 (0–23) 4.5 (0–28) (median range)] subscale [2.0 (0–15) 1.0 (0–29.5)] (P < 0.05). In two groups given D, but not group, there a significant improvement scores after 1 year. There decrease parathyroid hormone without concomitant increase calcium. Conclusions.  It appears be symptoms depression. Supplementation high doses seems ameliorate these indicating possible causal relationship.