Cross-protective immunity in calves conferred by a DNA adenine methylase deficient Salmonella enterica serovar Typhimurium vaccine
作者： V MOHLER , D HEITHOFF , M MAHAN , K WALKER , M HORNITZKY
DOI: 10.1016/J.VACCINE.2005.09.022
关键词:
摘要: Abstract The global trend towards intensive livestock production is associated with increased fecal oral pathogen transmission resulting in a high prevalence of Salmonella . Since many pathogenic serovars are often endemic to systems, it desirable develop vaccine that capable eliciting immunity more than one serovar. Here we examined whether immunization modified live enterica serovar Typhimurium strain lacking the DNA adenine methylase (Dam) conferred protection calves against heterologous S. Dublin challenge. Vaccinated animals challenged virulent exhibited significant attenuation clinical disease (improved attitude scores and reduced fever diarrhea) concomitant reduction shedding colonization mesenteric lymph nodes (MLN) compared non-vaccinated control animals. These data suggest vaccination dam − cross-protection cattle attributable challenge Dublin.
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