Pertussis toxin blocks autoreceptor-mediated inhibition of dopaminergic neurons in rat substantia nigra.
作者： R.B. Innis , G.K. Aghajanian
DOI: 10.1016/0006-8993(87)90690-1
关键词:
摘要: Abstract Rat substantia nigra was injected with 1 μg of purified pertussis toxin, a substance which inactivates the inhibitory guanine nucleotide regulatory unit adenylate cyclase. In comparison to saline-injected animals, toxin-treated animals showed almost no inhibition dopaminergic neurons in response dopamine applied iontophoretically or agonist (−)-apomorphine given intravenously. These results provide evidence that protein is involved as transducer mediating physiological actions autoreceptors.
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