Carditis at the interface between GERD and Helicobacter pylori infection.

摘要: Inflammation of the gastric cardia ('carditis') is a histological diagnosis. It seems reasonable to transfer criteria updated Sydney classification from distal stomach as long special inflammation esophagogastric junction lacking. The two best characterized causes carditis are Helicobacter pylori infection and gastroesophageal reflux disease (GERD). However, causal contribution interference these factors highly controversial, clinical relevance in terms eliciting symptoms or conferring an increased cancer risk. Variability studies on based conflicting concepts normal anatomy junction. Cardia-type mucosa (CM) apparently exists at birth tiny circular area, extends larger area adulthood. This implies that cardia-type largely metaplastic. Metaplastic CM may evolve lower esophagus consequence GERD. general phenomenon H. pylori-induced gastritis also involves cardia, irrespective whether lined by fundus-type CM. GERD pylori-negative individuals is, however, controversial. Prevalence patients fluctuates between 10 97%. Hence, because its high frequency low specificity, can currently not be considered entity. role for increasing incidence requires careful include accurate description with adequate biopsy protocols.