Hydroalcoholic extract of Emblica officinalis Gaertn. affords protection against PTZ-induced seizures, oxidative stress and cognitive impairment in rats.

摘要: Abstract The cognitive impairment seen in epileptics may be a consequence of either the underlying epileptogenic process alone or it could manifest on account use antiepileptic drugs that cause as an adverse effect both. Thus, there is need for can suppress epileptogenesis without contributing to or, if possible, by acting prevent development impairment. Emblica officinalis, Indian medicinal plant, has marked antioxidant property. seven days pretreatment 300, 500 and 700 mg/kg doses hydroalcoholic extract E. officinalis (HAEEO) administered intraperitoneally rats was evaluated pentylenetetrazole (PTZ) induced seizures, deficit oxidative stress markers viz malondialdehyde (MDA) glutathione. ip HAEEO completely abolished generalized tonic seizures also improved retention latency passive avoidance task. Further, dose-dependently ameliorated PTZ. These findings suggest potential used adjuvant treatment with drugs.