A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system.

摘要: We report the isolation of a novel human POU domain encoding gene named RDC-1. The RDC-1 encoded protein is highly related to potentially by rat brain-3 sequence and that Drosophila I-POU protein; outside region, unrelated any previously characterized protein. expressed almost exclusively in normal tissues transformed cells neural origin. In developing mouse fetus, spatially temporally restricted pattern suggests critical role differentiation neuronal tissues. addition, unique subset tumors peripheral nervous system including neuroepitheliomas Ewing's sarcomas but not neuroblastomas. Based on its structural characteristics expression pattern, we discuss potential functions for