Hyponeophagia and arousal in rats: effects of diazepam, 5-methoxy-N,N-dimethyltryptamine, d-amphetamine and food deprivation.

摘要: A modified hyponeophagia test is described as an animal model of anxiety. The effects 0, 0.3, 1.0, 3.0 and 10 mg/kg diazepam, given both acutely for 7 days pretest, were assessed in rats. Acutely, diazepam reduced over the dose range 0.3–3.0 but 10.0 produced sedation large variability. Chronically, dose-response relationships monotonic maximal effect was increased, suggesting that differential tolerance occurs to sedative, not anxiolytic, this drug. Increased food deprivation did mimic benzodiazepine on hyponeophagia, actually prolonged eating latency rats treated with 5-methoxy-N,N-dimethyltryptamine (2.5 mg/kg), which does support interpretation terms appetitive actions. An arousal hypothesis proposed supported by antagonism sedative d-amphetamine (0.5 mg/kg). Although male female used throughout, sex differences few these studies.