Corticotropin-releasing factor modulates dietary preference in nutritionally and physically stressed rats.

摘要: In order to evaluate the action of central nervous system Corticotropin-Releasing Factor (CRF) in control feeding behavior present studies employed a dietary self-selection task sensitive both overall appetite as well preferential intake familiar versus unfamiliar foods. Prior diet selection test, one group nutritionally stressed animals was fed protein deficient increase preference for foods relative replete subjects. Both CRF (0.05 and 0.5 µg ICV) physical restraint (30 min) attenuated selectively consumption novel food choice by without affecting concurrent food. Further, administration did not alter water or either suggesting that peptide produced stress dependent, enhanced response novelty general effect on appetite. The antagonist,α-helical CRF9–41 (1, 5 25 ICV), increased subjects pattern controls. Chlordiazepoxide (5 mg/kg) also this is anxiolytic complement paradigm. antagonist µg) reversed anorexia (0.5 induced stress. These results favor direct role endogenous systems coordinating behavioral responses