Relationship between endothelin-1 concentration and metabolic alterations typical of the insulin resistance syndrome.
作者： P.M. Piatti , L.D. Monti , L. Galli , G. Fragasso , G. Valsecchi
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摘要: The purpose of the study was to examine relationship between endothelin-1 (ET-1) concentration and metabolic variables characteristic insulin resistance syndrome ([IRS] hyperinsulinemia, resistance, hypertriglyceridemia, low high-density lipoprotein [HDL] cholesterol, visceral obesity, glycemic abnormalities). measurement circulating ET-1 is a well-recognized marker endothelial atherosclerotic cardiovascular disease. Two hundred subjects were divided into 3 groups. Group 1 included 50 with impaired glucose tolerance (IGT) or non—insulin-dependent diabetes mellitus (NIDDM) IRS. 2 IGT NIDDM without 100 normal as controls. levels higher in group versus groups women (11.2 ± 0.7 v 7.9 0.5 6.6 0.4 pg/mL, P 6.5 0.8 7.2 0.3
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