The etiology of hypertension in the metabolic syndrome part four: the systemic perspective--the role of the neuroendocrine and immune systems, and the challenge of integration.

摘要: Insulin resistance can be regarded to a cause, consequence, sustainer or marker of the wider neuroen- docrine dysfunction within which it occurs. In final part our series reviews, we examine systemic influences operate metabolic syndrome: endocrine system, central nervous system and immune system. We discuss strategies for integrating array information that is being gathered, in particular need computer simulation. also advocate move beyond linear paradigm 'cause effect' use causal networks think about this understand temperospatial organisation factors studied. Finally, draw together data, concepts hypotheses have reviewed over course these four arti- cles.