Localization of Evi-2 to chromosome 11: Linkage to other proto-oncogene and growth factor loci using interspecific backcross mice

摘要: A common site of ecotropic murine leukemia virus integration designated Evi-2 (ecotropic viral site-2) has been identified in BXH-2 myeloid tumors. As part experiments to determine whether a new proto-oncogene locus involved disease, we determined its chromosomal location. We mapped mouse Chromosome 11 using standard recombinant inbred strain and genetic backcross analysis. then the location relative other growth factor loci located on by interspecific The included this study were loci, Erbb, Erba, Rel, as well as, Il-3 (interleukin-3), Csfgm (granulocyte-macrophage colony stimulating factor), Trp53-1 (transforming protein p53). All except Erbb had previously with use somatic cell hybrids consequently their positions not known. One proto-oncogene, Erbb-2 (analogous neu proto-oncogene), one locus, Csfg (granulocyte colony-stimulating which also localized mice. Recombination between all was demonstrated, suggesting that may ultimately identify disease. This revealed number interesting conserved linkage groups man.