Estrogenic activity in women receiving an injectable progestogen for contraception

摘要: Abstract In order to determine whether an estrogen deficiency exists in women receiving 150 mg. of depo-medroxyprogesterone acetate every 3 months, 121 who had used this method contraception for 1 5 years were evaluated. Clinical evaluation revealed no subjective or objective sign deficiency, except small uterine size. The mean serum estradiol levels group patients (36 42 pg. per milliliter) the range found early follicular phase with ovulatory cycles. Nearly all measurements above postmenopausal women. It is concluded that these have ovaries which are functioning and secreting at relatively low constant demonstrable adverse clinical effects.