Expression of Bone Matrix Proteins in Human Breast Cancer: Potential Roles in Microcalcification Formation and in the Genesis of Bone Metastases

摘要: The skeleton is the privileged target of metastatic human breast cancer cells. Bone metastases are indeed found in virtually all advanced patients and generate major morbidity. high osteotropism cells suggests that they exhibit a selective affinity for mineralized tissues. observation mammary malignant able to induce hydroxyapatite crystals deposition within primary tumour can microenvironment favors crystallization calcium phosphate ions into bone specific hydroxyapatite. Osteonectin (OSN), osteopontin (OPN) sialoprotein (BSP), 3 matrix proteins involved mineralization, expressed cancers. BSP, an RGD (Arg-Gly-Asp) containing phosphoprotein, initiates mediates attachment osteoclast same prior their resorption. Detection BSP at both protein mRNA levels cell lines (MCF-7, T47-D MDA-MB 231) indicates synthesize directly rather than uptaking it from serum. Interestingly, level expression correlates with development poor survival. These data suggest ectopic could be conferring osteotropic properties circulating observations open new alleys investigation identification molecular mechanisms responsible genesis metastases.