Cell motility and breast cancer metastasis
作者： Marc E. Bracke , Daan De Maeseneer , Veerle Van Marck , Lara Derycke , Barbara Vanhoecke
DOI: 10.1007/978-1-4020-5867-7_4
关键词:
摘要: Motility and invasion of breast cancer cells are the result concerted action a number cell activities: directional migration underpinned by dynamic organisation cytoskeletal components (actin micro-filaments microtubules), establishment disruption cell-matrix homotypic/heterotypic cell-cell adhesions, extracellular proteolysis. Metastasis formation is not only related to motility, but also necessitates collaboration other, coined “host” cells. Newly discovered ligand-receptor interactions between these host elements offer molecular explanation for Paget’s “seed soil” hypothesis, indicate new targets possible anti-metastatic therapeutic agents
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