Prospective cohort studies of association between family history of liver cancer and risk of liver cancer

摘要: Uncertainty remains on the relationship between a family history of liver cancer and risk in prospective cohort studies general population. Thus, we examined this association 133,014 participants Shanghai Women's Men's Health Studies. Family was categorized through dichotomous proportional score approaches. Hazard ratios (HRs) 95% confidence intervals (CIs) were derived using Cox hazards models with adjustment for potential confounders. A meta-analysis observational December 2013 relation to also performed. Study-specific estimates combined fixed or random effects depending whether significant heterogeneity detected. For Studies, 299 cases identified during follow-up 2010. associated both binary indicator (HR = 2.60, CI: 1.77-3.80) (high-risk vs. minimal-risk category: HR 3.03, 1.73-5.31), increasing HRs categories. The showed an increased those (relative 2.55, 2.05-3.16). related Chinese This is particularly high affected mother. "dose-response" might further facilitate future prevention programs identifying individuals highest risk.