Prevalence of treatment-resistant hypertension and important associated factors—results from the Swedish Primary Care Cardiovascular Database

摘要: Abstract We aimed to describe the prevalence, treatment, and associated comorbidity of treatment-resistant hypertension (TRH). This registry-based cohort study from The Swedish Primary Care Cardiovascular Database assessed 53,090 hypertensive patients attending primary care. Patients adherent antihypertensive treatment measured by pharmacy fills with proportion days covered ≥80% were included. prevalence TRH was 17% when considering all current definitions. Adherence mineralocorticoid receptor antagonists differed between TRH- non-TRH (8 vs. 4%). Higher frequencies (prevalence ratio 95% confidence intervals) diabetes mellitus (1.59, 1.53–1.66), heart failure (1.55, 1.48–1.64), atrial fibrillation (1.33, 1.27–1.40), ischemic disease (1.25, 1.20–1.30), chronic kidney (1.38, 1.23–1.54) seen in compared without TRH. These findings, a population valid data on medication adherence, emphasize broad preventive approach for these high-risk patients.