Effects of intensive blood-pressure control in type 2 diabetes mellitus.

摘要: After 1 year, the mean systolic blood pressure was 119.3 mm Hg in intensivetherapy group and 133.5 standard-therapy group. The annual rate of primary outcome 1.87% intensive-therapy 2.09% (hazard ratio with intensive therapy, 0.88; 95% confidence interval [CI], 0.73 to 1.06; P = 0.20). rates death from any cause were 1.28% 1.19% two groups, respectively ratio, 1.07; CI, 0.85 1.35; 0.55). stroke, a prespecified secondary outcome, 0.32% 0.53% 0.59; 0.39 0.89; 0.01). Serious adverse events attributed antihypertensive treatment occurred 77 2362 participants (3.3%) 30 2371 (1.3%) (P<0.001). Conclusions In patients type 2 diabetes at high risk for cardiovascular events, targeting less than 120 Hg, as compared 140 did not reduce composite fatal nonfatal major events. (ClinicalTrials.gov number, NCT00000620.)