ATG9 regulates autophagosome progression from the endoplasmic reticulum in Arabidopsis

作者: Xiaohong Zhuang , Kin Pan Chung , Yong Cui , Weili Lin , Caiji Gao

DOI: 10.1073/PNAS.1616299114

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摘要: Autophagy is a conserved pathway for bulk degradation of cytoplasmic material by a double-membrane structure named the autophagosome. The initiation of autophagosome formation requires the recruitment of autophagy-related protein 9 (ATG9) vesicles to the preautophagosomal structure. However, the functional relationship between ATG9 vesicles and the phagophore is controversial in different systems, and the molecular function of ATG9 remains unknown in plants. Here, we demonstrate that ATG9 is essential for endoplasmic …

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