Ablative CO2 fractional resurfacing in treatment of thermal burn scars: an open-label controlled clinical and histopathological study.

摘要: SummaryIntroduction Burn scars can cause permanent disfiguring problems with limited treatments available. Objectives To assess and correlate the clinical histopathological effects of fractional CO2 laser on thermal burns in a controlled study. Methods Fifteen patients 11 hypertrophic four keloidal received three sessions every 4–6 weeks. Half scar was untreated as control. Clinical evaluation by Vancouver, PSOAS scores, photography before, monthly, 3 months after last session performed. Ten were evaluated histopathologically standard H&E, Masson trichrome, Elastica von Gieson special stains. Results Hypertrophic (HTSs) showed textural improvement significant decrease POSAS observer, patient scores end follow-up period laser-treated area (P = 0.011, 0.017 0.018, respectively) unlike scars. Histopathology revealed thickness HTSs only (P < 0.001) well collagen bundle density upper dermis both types scars. Conclusions Fractional is possible safe effective modality for treatment burn achieved clinically histopathologically.