Vitamin D receptor gene polymorphisms and esophageal cancer risk in a Chinese population: a negative study
作者： Haiyong Gu , Xu Wang , Liang Zheng , Weifeng Tang , Changqing Dong
DOI: 10.1007/S12032-013-0827-X
关键词:
摘要: Vitamin D receptor (VDR) gene polymorphisms have been reported to influence susceptibility some malignant cancers. However, there were few published findings on the association between VDR and esophageal cancer susceptibility. Our investigation was aimed obtain a precise estimation of We conducted hospital-based case–control study evaluate genetic effects functional single-nucleotide rs2107301 T>C, rs2228570 C>T, rs1989969 C>T rs11568820 G>A development cancer. A total 629 squamous cell carcinoma (ESCC) cases 686 controls enrolled for this study. The genotypes determined using ligation detection reaction method. There no significant associations four variants ESCC risk. Stratified analyses indicated significantly increased risk associated with T>C polymorphism among patients who drinking. These demonstrated that may be modified by lifestyle factors such as results should validated in larger well-designed studies future.
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