Sex differences in the interactive effects of early life stress and the endocannabinoid system

摘要: Sex differences in both the endocannabinoid system and stress responses have been established for decades. While there is ample evidence that sexes respond differently to involved this response, what less clear whether mediates response sexes. Also, do similarly exogenous cannabinoids (CBs) following stress? Can administration of CBs normalize effects if so, does happen male female subjects? This review will attempt delineate induced neurochemical alterations resulting behavioral changes across periods development: prenatal, early neonatal or adolescent males females. Within frame work, we then examine illustrate determined by history animal. The theoretical framework endeavor relates adverse childhood experiences (ACE) increasing substance abuse, depression anxiety possibility individuals with high ACE scores may consume "self-medicate". Overall, see while are instances where "normalize" produced stress, normalization not occur all animal models any sort consistency. most compelling report CB appears behaviors altered shows minimal between (Alteba et al., 2016). stark contrast majority studies on included show quite divergent, fact opposite, Frequently a disconnect often, greater stressed animals compared non-stressed controls. as well others reviewed here support concept different experiencing these equal However, due wide variety stressors used range ages when applied, additional careful warranted fully understand interactive In general, findings statement self-administration an effective treatment maltreatment either Certainly should draw attention clinicians working children, adolescents adults exposed trauma provide some perspective dysregulation trauma, complex actions based unique factors men women.