Long lasting consequences of cannabis exposure in adolescence.

摘要: Despite the increasing use of cannabis among adolescents, there are little and often contradictory studies on long-term neurobiological consequences consumption in juveniles. Adolescence is a critical phase for cerebral development, where endocannabinoid system plays an important role influencing release action different neurotransmitters. Therefore, strong stimulation by psychoactive component marijuana, delta-9-tetrahydrocanabinol (THC), might lead to subtle but lasting changes that can affect adult brain functions behaviour. The literature here summarized experimental animal models, puts forward heavy adolescence may induce circuits ending altered emotional cognitive performance, enhanced vulnerability more harmful drugs abuse selected individuals, represent risk factor developing schizophrenia adulthood. potential problems arising relation marijuana suggest this developmental vulnerable period persistent adverse effects cannabinoids.