Genetic Diversity of Brazilian Aedes aegypti: Patterns following an Eradication Program

摘要: Background: Aedes aegypti is the most important vector of dengue fever in Brazil, where severe epidemics have recently taken place. Ae. Brazil was subject an intense eradication program 1940s and 50s to control yellow fever. largest country declared free this mosquito by Pan-American Health Organization 1958. Soon after relaxation program, reappeared country, early 1980s had been reported. The aim study analyze present-day genetic patterns populations Brazil. Methodology/Principal Findings: We studied variation samples 11 widely spread Ae. aegypti based on 12 well-established microsatellite loci. Our principal finding that Brazilian form two distinct groups, one northwest southeast country. These two groups affinities northern South American countries Caribbean, respectively. This consistent with what has been reported for other markers such as mitochondrial DNA allele frequencies at insecticide resistance gene, kdr. Conclusions/Significance: conclude present day are more with a complete species recent past followed re-colonization, rather than the alternative possibility expansion from residual pockets refugia. At least colonizations are likely taken place, one (e.g., Venezuela) founded northwestern group, the Caribbean southeastern group. proposed source areas were never aegypti.