Kinetic crystallization separation process of the inositol isomers by controlling metastable zones

摘要: Abstract D-chiro-inositol (DCI) is prepared by the immobilized enzyme reaction which uses myo-inositol (MI) as substrate and conversion rate about 13%. The aim of this study was to develop a separation method for high purity DCI crystals from solution including low only crystallization process. We succeeded in separating 96% water cooling crystallization, but it presumed that scale-up difficult. Although we tried anti-solvent similar were not obtained. Therefore, proposed process controlling metastable zones. desired compound controlled process, because solid–liquid achieved before zone. By using method, 97% yield per batch 50%, actual improved last mother liquor returns into following batch. When repeated, reproduced robustness proved. It expected will be successful, purification could applicable systems such isomers analogs.