The effect of FK506 versus cyclosporine on glucose and lipid metabolism--a randomized trial.

摘要: In order to evaluate the effect of cyclosporine (CsA) versus FK506 on glucose and lipid metabolism, an oral tolerance test (OGTT) was performed in 101 patients after orthotopic liver transplantation (OLT) (mean interval OLT: 511 days). The graft recipients had been randomized prospectively two groups prior OLT receive either immunosuppression with CsA, azathioprine, corticosteroids (CsA group) or (FK group). Along OGTT, serum insulin, insulin C-peptide glucagon as well lipids were monitored. There no statistically significant difference occurrence impaired (IGT) manifest diabetes mellitus disease between groups. fact, not a single patient developed new-onset any group. male female patients, levels cholesterol triglycerides increased significantly under CsA treatment OLT. Cholesterol higher group men, women this marked, but significant. While treatment, there such men. conclusion, both proved have similar effects while different spectrum alterations.