Protective efficacy of 2-PAMCl, atropine and curcumin against dichlorvos induced toxicity in rats.
作者： Preeti Yadav Preeti Yadav , SE Jadhav , Vinesh Kumar Vinesh Kumar , KK Kaul , SC Pant
DOI: 10.2478/V10102-012-0001-X
关键词:
摘要: The effect of 2- pyridine aldoxime methyl chloride (2-PAMCl) and atropine with or without curcumin was investigated in dichlorvos (2,2-dichlorovinyl dimethyl phosphate; DDVP) induced toxicity rats. Rats were exposed to DDVP (2 mg/kg sub-cutaneously) once daily for the period 21 days. Post exposure, rats further treated 2-PAMCl (50 intramuscular, daily) + (10 mg/kg, i.m. (200 mg/kg; oral; We observed a significant increase lipid peroxidation (LPO), reactive oxygen species (ROS), oxidized glutathione (GSSG), while there decrease antioxidant enzymes, brain acetylcholinesterase (AChE) 5-hydroxy tryptamine (5-HT) activity on exposure These alterations restored significantly by co-administration Curcumin when co-supplemented also protected serum aspartate aminotransferase (AST) AChE 5-HT level animals sub-chronically DDVP. Histopathological observations along biochemical changes rat blood tissues revealed protection offered against results indicate that DDVP-induced can be individually, however, co-supplementation provides more pronounced protection, concerning particularly neurological disorders.
sci-hub.se 参考文章(32)
Samuel Peña-Llopis, M.Dolores Ferrando, Juan B Peña, Fish tolerance to organophosphate-induced oxidative stress is dependent on the glutathione metabolism and enhanced by N-acetylcysteine Aquatic Toxicology. ,vol. 65, pp. 337- 360 ,(2003) , 10.1016/S0166-445X(03)00148-6
Abdullah T. Demiryurek, Ataman Kose, Nurullah Gunay, Beril Kose, Ali R. Ocak, Ozcan Erel, Effects of atropine and pralidoxime pretreatment on serum and cardiac oxidative stress parameters in acute dichlorvos toxicity in rats. Pesticide Biochemistry and Physiology. ,vol. 97, pp. 249- 255 ,(2010) , 10.1016/J.PESTBP.2010.03.004
Yumei Fu, Shizhong Zheng, Jianguo Lin, Jan Ryerse, Anping Chen, Curcumin Protects the Rat Liver from CCl4-Caused Injury and Fibrogenesis by Attenuating Oxidative Stress and Suppressing Inflammation Molecular Pharmacology. ,vol. 73, pp. 399- 409 ,(2008) , 10.1124/MOL.107.039818
Nidhi Dwivedi Nidhi Dwivedi, SJS Flora, Concomitant exposure to arsenic and organophosphates on tissue oxidative stress in rats Food and Chemical Toxicology. ,vol. 49, pp. 1152- 1159 ,(2011) , 10.1016/J.FCT.2011.02.007
Paul J. Hissin, Russell Hilf, A fluorometric method for determination of oxidized and reduced glutathione in tissues Analytical Biochemistry. ,vol. 74, pp. 214- 226 ,(1976) , 10.1016/0003-2697(76)90326-2
Manal E.A. Elhalwagy, Nevine S. Darwish, Enass M. Zaher, Prophylactic effect of green tea polyphenols against liver and kidney injury induced by fenitrothion insecticide Pesticide Biochemistry and Physiology. ,vol. 91, pp. 81- 89 ,(2008) , 10.1016/J.PESTBP.2008.01.006
Ismail Celik, Huseyin Suzek, Subacute effects of methyl parathion on antioxidant defense systems and lipid peroxidation in rats Food and Chemical Toxicology. ,vol. 46, pp. 2796- 2801 ,(2008) , 10.1016/J.FCT.2008.05.012
Ismail Celik, Ismail Isik, Neurotoxic effects of subacute exposure of dichlorvos and methyl parathion at sublethal dosages in rats Pesticide Biochemistry and Physiology. ,vol. 94, pp. 1- 4 ,(2009) , 10.1016/J.PESTBP.2009.02.003
Megha Mittal, S.J.S. Flora, Effects of individual and combined exposure to sodium arsenite and sodium fluoride on tissue oxidative stress, arsenic and fluoride levels in male mice. Chemico-Biological Interactions. ,vol. 162, pp. 128- 139 ,(2006) , 10.1016/J.CBI.2006.05.018
D.J. Socci, K.B. Bjugstad, H.C. Jones, J.V. Pattisapu, G.W. Arendash, Evidence That Oxidative Stress Is Associated with the Pathophysiology of Inherited Hydrocephalus in the H-Tx Rat Model Experimental Neurology. ,vol. 155, pp. 109- 117 ,(1999) , 10.1006/EXNR.1998.6969