N-[(piperazinyl)hetaryl]arylsulfonamide compounds with affinity for the dopamine d3 receptor

摘要: The invention relates to N-[(piperazinyl)hetaryl]arylsulfonamide compounds of the general formula (I ) in which Q is a bivalent, 6-membered heteroaromatic radical possesses 1 or 2 N atoms as ring members and optionally carries one two substituents Ra is/are selected, independently each other, from halogen, CN, NO2, C02R4, COR5, C1-C4-alkyl C1-C4-haloalkyl; Ar phenyl Rb, selected C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C4-alkyl C1-C4-haloalkyl, with it also being possible for radicals Rb are bonded adjacent C be together C3-C4-alkylene; R1 hydrogen, C1-C4-alkyl, C3-C6-cycloalkyl-C1-C4-alkyl, C1-C4-hydroxyalkyl, C1-C4-alkoxy-C1-C4-alkyl, C3-C4-alkenyl C3-C4-alkynyl; n, R1, R2, R3, R4 R5 having meanings given patent claims, N-oxides physiologically tolerated acid addition salts these pharmaceutical compositions comprise at least compound claimed claims 10 and/or salt I an N-oxide I, where appropriate acceptable carriers auxiliary substances treating diseases respond influencing by dopamine D3 receptor antagonists agonists, particular central nervous system disturbances kidney function.