Design and Analysis of the 4-Anilinoquin(az)oline Kinase Inhibition Profiles of GAK/SLK/STK10 Using Quantitative Structure-Activity Relationships.
作者： Christopher R. M. Asquith , Tuomo Laitinen , James M. Bennett , Carrow I. Wells , Jonathan M. Elkins
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摘要: … nanomolar range for SLK/STK10/… inhibitor of nearly all 6 targets, only STK16 showing very limited binding (K i =42 μM). We observed potent inhibition of GAK at K i =6.7 nM, with SLK/…
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