Predictors of Competing Mortality in Advanced Head and Neck Cancer

摘要: PURPOSE Death from noncancer causes (competing mortality) is an important event in head and neck cancer, but studies identifying predictors of this are lacking. We sought to identify competing mortality develop a risk stratification model for events. PATIENTS AND METHODS Cohort study 479 patients with stage III IV carcinoma the diagnosed between August 1993 November 2004. Patients were treated on consecutive prospective clinical trials involving organ-preserving chemoradiotherapy surgery. used multivariable risks regression models analyze factors associated cumulative incidence mortality, locoregional distant failure, second malignancies as first Results Median follow-up was 52 months median survivors. The 5-year 19.6% (95% CI, 15.8 23.4). On analysis, female sex (hazard ratio [HR], 1.72; 95% 1.13 2.63), increasing age (HR, 1.30; 1.04 1.62), Charlson Comorbidity Index 1.24; 1.05 1.47), decreasing body mass index 0.33; 0.13 0.84), distance traveled treating center 0.65; 0.44 0.98). zero, one, two, > or = three had 8.9% 3.0% 14.8%), 12.4% 7.0% 17.8%), 22.1% 14.5% 29.7%), 39.3% 28.6% 50.1%), respectively. CONCLUSION Competing advanced cancer several demographic health status characteristics. Analyses may be useful outcomes reporting designing trials.