FATTY ACID AND PHOSPHOLIPID COMPOSITION OF THE CELLULAR SLIME MOLD, DICTYOSTELIUM DISCOIDEUM. THE OCCURRENCE OF PREVIOUSLY UNDESCRIBED FATTY ACIDS.

摘要: The cellular slime mold Dictyostelium dticoideum has been extensively studied (1) because of the unique series morphological transitions that wild type undergoes. From single, vegetative cells, organisms pass through complex aggregation, migration, and culmination, leadii finally to spore formation. Sussmenn (2) produced a number stable, aggregateless mutants remain permanently in stage as single ameboid cells.’ One these was used present study order avoid complicating factors transition. Previous investigation lipids diecoideum its mutant Agg 204 had limited characterisation steroid, AZ-stigmasten3&ol, demonstration biosynthesis from acetate mevalonate (3). Stigmastenol is large quantities by disco&&urn felt be related activity aggregation-inducing factor, acrasin (4). fatty acids phosphatides are described this paper. acid composition each determined. Evidence presented for considerable molecular heterogeneity within several classes phosphatides. contain an unusually high percentage unsaturated acids. Of major interest presence, amounts, three new dienoic long chain whose structures have established 5,9-hexadecadienoic acid, 5,9-octadecadienoic 5,1 l-octadecadienoic acid. Under appropriate conditions growth, two other acids, 9-heptadecenoic 5,9-heptadecadienoic normally small can made accumulate. Studies pathways accompanying paper (5).