Cyclin D1 protein expression is related to clinical progression in laryngeal squamous cell carcinomas.
作者： Pasquale Capaccio , Giancarlo Pruneri , Nadia Carboni , Angelo Virgilio Pagliari , Roberto Buffa
DOI: 10.1017/S0022215100138149
关键词:
摘要: The expression of cyclin D1 gene was investigated in 74 laryngeal squamous cell carcinomas (LSCCs) order to determine its clinical and prognostic value. Overexpression detected immunohistochemically using DCS6 monoclonal antibody on formalin-fixed, paraffin-embedded tissue sections. Cyclin 22 the cases (30 per cent), thirteen which presented nodal metastases (59 cent); patients without any detectable protein expression, six (12 cent). found five cent specimens normal mucosa, eight those with low-grade dysplasia 20 high-grade dysplasia. A statistically significant association between supraglottic site (p < 0.05), tumour extension 0.001), presence lymph node advanced stage 0.001). analysis is an important tool selection LSCC aggressive course.
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sci-hub.se 参考文章(32)
A. Hart, A. Balm, R. Michalides, E. Wientjens, B. Loftus, N. Van Veelen, Overexpression of Cyclin D1 Correlates with Recurrence in a Group of Forty-seven Operable Squamous Cell Carcinomas of the Head and Neck Cancer Research. ,vol. 55, pp. 975- 978 ,(1995)
C Cordon-Cardo, Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia. American Journal of Pathology. ,vol. 147, pp. 545- 560 ,(1995)
Pedro Jares, Pedro L Fernández, Elías Campo, Alfons Nadal, Francesc Bosch, Gemma Aiza, Iracema Nayach, José Traserra, Antonio Cardesa, None, PRAD-1/cyclin D1 gene amplification correlates with messenger RNA overexpression and tumor progression in human laryngeal carcinomas. Cancer Research. ,vol. 54, pp. 4813- 4817 ,(1994)
Jirina Bartkova, Jiri Lukas, Jiri Bartek, Barry Gusterson, Heiko Müller, Michael Strauss, Abnormal Patterns of D-Type Cyclin Expression and G1 Regulation in Human Head and Neck Cancer Cancer Research. ,vol. 55, pp. 949- 956 ,(1995)
S Ozawa, M Kitajima, M Terada, N Ando, H Shinozaki, M Ueda, H Tsuruta, Cyclin D1 amplification as a new predictive classification for squamous cell carcinoma of the esophagus, adding gene information. Clinical Cancer Research. ,vol. 2, pp. 1155- 1161 ,(1996)
G Casey, R Smith, D McGillivray, G Peters, C Dickson, Characterization and chromosome assignment of the human homolog of int-2, a potential proto-oncogene. Molecular and Cellular Biology. ,vol. 6, pp. 502- 510 ,(1986) , 10.1128/MCB.6.2.502
Bruce J. Davidson, William M. Lydiatt, Megan P. Abate, Stimson P. Schantz, R.S.K. Chaganti, Cyclin D1 abnormalities and tobacco exposure in head and neck squamous cell carcinoma Head and Neck-journal for The Sciences and Specialties of The Head and Neck. ,vol. 18, pp. 512- 521 ,(1996) , 10.1002/(SICI)1097-0347(199611/12)18:6<512::AID-HED5>3.0.CO;2-5
J. Helen Leonard, John H. Kearsley, Georgia Chenevix-Trench, Nicholas K. Hayward, Analysis of gene amplification in head-and-neck squamous-cell carcinomas International Journal of Cancer. ,vol. 48, pp. 511- 515 ,(1991) , 10.1002/IJC.2910480406
Timo S. Atula, Reidar Grénman, Matti J. Varpula, Timo J. I. Kurki, Pekka-Juhani Klemi, Palpation, ultrasound, and ultrasound‐guided fine‐needle aspiration cytology in the assessment of cervical lymph node status in head and neck cancer patients Head and Neck-journal for The Sciences and Specialties of The Head and Neck. ,vol. 18, pp. 545- 551 ,(1996) , 10.1002/(SICI)1097-0347(199611/12)18:6<545::AID-HED9>3.0.CO;2-2
L Pignataro, P Capaccio, G Pruneri, N Carboni, N Fracchiolla, R Richelda, G Scaramellini, A Neri, R Buffa, p53 and cyclin D1 protein expression in glottic laryngeal squamous cell carcinomas involving the anterior commissure (pT1bN0M0). International Journal of Oncology. ,vol. 9, pp. 553- 557 ,(1996) , 10.3892/IJO.9.3.553