Interrelation between sex hormones and plasma sex hormone-binding globulin and hemoglobin A1c in healthy postmenopausal women.
作者： Gabrielle Page-Wilson , Alessandra C. Goulart , Kathryn M. Rexrode
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摘要: Background: Androgenicity, as measured by low sex hormone-binding globulin (SHBG) and elevations in testosterone free androgen index (FAI), is associated with adverse cardiovascular (CV) outcomes, possibly due to effects on insulin resistance glycemia.Methods: Glycosylated hemoglobin (HbA1c) concentration, SHBG, hormones were available 200 nondiabetic postmenopausal women who not using hormone therapy (HT) the Women’s Health Study. Of these, 98 disease (CVD) cases; remainders matched controls. To achieve normality, continuous values log transformed geometric means calculated. Associations between HbA1c examined general linear models (GLM), partial correlations, multiple regression analyses.Results: Lower SHBG levels higher FAI found among CVD cases, all analyses adjusted for this factor. In GLM, of observed highest quartiles ...
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