Sex hormone-binding globulin and type 2 diabetes mellitus
作者： Trang N. Le , John E. Nestler , Jerome F. Strauss , Edmond P. Wickham
DOI: 10.1016/J.TEM.2011.09.005
关键词:
摘要: Sex hormone-binding globulin (SHBG) has emerged as one of the multiple genetic and environmental factors that potentially contribute to pathophysiology type 2 diabetes mellitus (T2DM). In addition epidemiologic studies demonstrating a consistent relationship between decreased levels serum SHBG incident T2DM, recent also reveal transmission specific polymorphisms in gene influence risk T2DM. At molecular level, interactions its receptors various target tissues suggest physiologic roles for are more complex than simple transport sex hormones serum. Taken together, these data provide support an expanded role insulin resistance
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