High-Dose Vitamin D Intervention in Infants—Effects on Vitamin D Status, Calcium Homeostasis, and Bone Strength
作者： Elisa Holmlund-Suila , Heli Viljakainen , Timo Hytinantti , Christel Lamberg-Allardt , Sture Andersson
DOI: 10.1210/JC.2012-1575
关键词:
摘要: Context: Guidelines in Finland recommend 10 μg of vitamin D3 daily for all infants. Recent observations suggest that this may be insufficient to maintain optimal serum 25-hydroxyvitamin D (S-25-OHD). Objective: The aim the study was evaluate effects various doses and determine a dose ensuring S-25-OHD at least 80 nmol/liter infants without signs excess. Design: We conducted randomized double-blind intervention study. Cord blood obtained birth S-25-OHD; 113 were receive 10, 30, or 40 μg/d from age 2 wk 3 months. Setting: An investigator-initiated performed single maternity hospital Helsinki, Finland. Main Outcome Measures: S-25-OHD, calcium homeostasis, skeletal characteristics evaluated with peripheral quantitative computed tomography Results: Baseline similar three groups (median, 53 nmol/liter). At months, mean values 88, 124, 153 ...
oup.com
endojournals.org
endocrine.org 参考文章(41)
Heather B Del Valle, A Catharine Ross, Ann L Yaktine, Christine L Taylor, Dietary Reference Intakes for Calcium and Vitamin D ,(2013)
Bruce W Hollis, Carol L Wagner, Assessment of dietary vitamin D requirements during pregnancy and lactation. The American Journal of Clinical Nutrition. ,vol. 79, pp. 717- 726 ,(2004) , 10.1093/AJCN/79.5.717
Glenville Jones, Pharmacokinetics of vitamin D toxicity The American Journal of Clinical Nutrition. ,vol. 88, ,(2008) , 10.1093/AJCN/88.2.582S
Catherine M. Gordon, Avery LeBoff Williams, Henry A. Feldman, Jessica May, Linda Sinclair, Alex Vasquez, Joanne E. Cox, Treatment of hypovitaminosis D in infants and toddlers. The Journal of Clinical Endocrinology and Metabolism. ,vol. 93, pp. 2716- 2721 ,(2008) , 10.1210/JC.2007-2790
Lavjay Butani, Alok Kalia, Idiopathic hypercalciuria in children—how valid are the existing diagnostic criteria? Pediatric Nephrology. ,vol. 19, pp. 577- 582 ,(2004) , 10.1007/S00467-004-1470-8
Valencia P. Walker, Xiaoran Zhang, Ida Rastegar, Philip T. Liu, Bruce W. Hollis, John S. Adams, Robert L. Modlin, Cord Blood Vitamin D Status Impacts Innate Immune Responses The Journal of Clinical Endocrinology and Metabolism. ,vol. 96, pp. 1835- 1843 ,(2011) , 10.1210/JC.2010-1559
Kinga A. Szucs, American Academy of Pediatrics Section on Breastfeeding. Journal of Human Lactation. ,vol. 27, pp. 378- 379 ,(2011) , 10.1177/0890334411422704
Pamela Mahon, Nicholas Harvey, Sarah Crozier, Hazel Inskip, Sian Robinson, Nigel Arden, Rama Swaminathan, Cyrus Cooper, Keith Godfrey, Low maternal vitamin D status and fetal bone development: cohort study. Journal of Bone and Mineral Research. ,vol. 25, pp. 14- 19 ,(2010) , 10.1359/JBMR.090701
Heli T Viljakainen, Anna-Mari Natri, Merja Kärkkäinen, Minna M Huttunen, Anette Palssa, Jette Jakobsen, Kevin D Cashman, Christian Mølgaard, Christel Lamberg-Allardt, A Positive Dose–Response Effect of Vitamin D Supplementation on Site-Specific Bone Mineral Augmentation in Adolescent Girls: A Double-Blinded Randomized Placebo-Controlled 1-Year Intervention Journal of Bone and Mineral Research. ,vol. 21, pp. 836- 844 ,(2006) , 10.1359/JBMR.060302
Bright I. Nwaru, Suvi Ahonen, Minna Kaila, Maijaliisa Erkkola, Anna-Maija Haapala, Carina Kronberg-Kippilä, Riitta Veijola, Jorma Ilonen, Olli Simell, Mikael Knip, Suvi M. Virtanen, Maternal diet during pregnancy and allergic sensitization in the offspring by 5 yrs of age: a prospective cohort study. Pediatric Allergy and Immunology. ,vol. 21, pp. 29- 37 ,(2010) , 10.1111/J.1399-3038.2009.00949.X