Pharmacotherapeutic management of locally advanced prostate cancer: current status.
作者： Jarad M. Martin , Stephane Supiot , Dominik R. Berthold
DOI: 10.2165/11591500-000000000-00000
关键词:
摘要: Locally advanced prostate cancer (LAPC) is a heterogeneous entity usually embracing T3-4 and/or pelvic lymph-node-positive disease in the absence of established metastases. Outcomes for LAPC with single therapies have traditionally been poor, leading to investigation adjuvant therapies. Prostate hormonally sensitive tumour, which responds pharmacological manipulation androgen receptor or its testosterone-related ligands. As such, deprivation therapy (ADT) has become an important strategy treatment LAPC, particularly patients managed primarily radiotherapy. Such results generally not replicated surgical patients. With increased use ADT come improved awareness numerous toxicities associated long-term these agents, as well development strategies minimizing exposure and actively managing adverse effects. Several trials are exploring agents enhance radiation cell sensitivity application docetaxel, agent proven efficacy metastatic, castrate-resistant setting. The recent work showing activity cabazitaxel, sipuleucel-T abiraterone post-docetaxel setting will see investigated conjunction definitive surgery
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