Toxicity of culture material of Fusarium verticillioides strain MRC 826 to nonhuman primates.

摘要: We conducted a chronic feeding study in vervet monkeys (Cercopithecus aethiops) over 13.5 years. The experimental design consisted of two dietary treatment groups, each including males and females, fed varying levels culture material Fusarium verticillioides (Sacc.) Nirenberg (= F. moniliforme Sheldon) strain MRC 826 mixed into their daily food ration. Two females were included as controls. blood chemical analyses bimonthly recorded all clinical signs during the course experiment. took liver biopsies at various stages initial phase Several terminated extremis Detailed feed intake profiles determined 5 years after experiment began, fumonisin B (FB) mycotoxin content was final apparent FB consumption patterns related to changes observed biochemical parameters urine, function enzymes creatinine clearance well differential counts sphingolipid serum urine. An no-effect threshold for kidney damage is estimated be between 0.11 0.18 mg FB/kg body weight (bw)/day, which corresponds contamination level 8.21 13.25 bw diet. Apart from effects on kidney, wide variety parameters, cholesterol creatine kinase, also adversely affected. white red cells, significantly decreased treated animals. sphinganine sphingosine/sphinganine ratio, monitored toward end experiment, increased both low-dose high-dose present provides important information about diversity lesions induced by dosage fumonisins used long-term studies nonhuman primates.