Radiopaque iodinated copolymeric nanoparticles for X-ray imaging applications.

摘要: Recently we described iodinated homopolymeric radiopaque nanoparticles of 28.9+/-6.3 nm dry diameter synthesized by emulsion polymerization 2-methacryloyloxyethyl(2,3,5-triiodobenzoate) (MAOETIB). The nanoparticle aqueous dispersion, however, was not stable and tended to agglomerate, particularly at weight concentration dispersed above approximately 0.3%. agglomeration rate increases as the in phase rises prevents potential vivo use contrast agent for medical X-ray imaging. Here describe efforts overcome this limitation synthesis copolymeric 25.5+/-4.2 diameter, copolymerization monomer, MAOETIB, with a low glycidyl methacrylate (GMA). surface resulting is far more hydrophilic than that polyMAOETIB (PMAOETIB) nanoparticles. Therefore, P(MAOETIB-GMA) are significantly against continuous phase. After intravenous injection rats mice (including those liver cancer model) CT-imaging revealed significant enhanced visibility blood pool 30 min after injection. Later, lymph nodes, spleen strongly due uptake reticuloendothelial system. This favorably enabled differentiation cancerous from healthy tissue suggests our particles tumor imaging nodes.