Relationship between ITPA polymorphisms and hemolytic anemia in HCV-infected patients after ribavirin-based therapy: a meta-analysis
作者： Daniel Pineda-Tenor , Monica Garcia-Alvarez , Maria A Jimenez-Sousa , Sonia Vazquez-Moron , Salvador Resino
DOI: 10.1186/S12967-015-0682-Y
关键词:
摘要: Background There is growing evidence that variations in the gene encoding inosine triphosphate pyrophosphohydrolase (ITPase), known as triphosphatase (ITPA), are related to hemolytic anemia, which frequently observed among hepatitis C virus (HCV)-infected patients receiving ribavirin (RBV)-based therapy. We performed a meta-analysis of all eligible studies assessing ITPA polymorphisms RBV-induced anemia HCV-infected published PubMed, Embase and Cochrane library prior end 2014.
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