Cardiovascular effects of a newly synthesized cardiotonic agent (TA-064) on normal and diseased hearts*

摘要: A new inotropic agent, TA-064, (−)- α -(3,4-dimethoxyphenethylaminomethyl)-4-hydroxybenzylalcohol, was shown to have strong effects in experimental animals. Its effectiveness and associated adverse were tested humans invasively (n = 6) noninvasively 17). Increasing doses of intravenous infusion (1, 2, 4 μ g/kg/min) increased plasma levels 15, 35, 82 ng/ml, respectively, resulting marked increases the peak rate left ventricular pressure rise (dP/dt) (1,450 ± 63 3,042 349 mm Hg/s) (mean standard error mean [SEM], p −1 ) (p 2