Mechanism of Action of Inotropic Agents in Heart Failure

摘要: In 1785 William Withering in his accounts of Foxglove, reported the beneficial effects digitalis dropsy [1]. Thus, use drugs with positive inotropic management heart failure was introduced clinical practice. Catecholamines appeared several decades after introduction and presently a large number such catecholamines are available for growing agents undergoing investigation. Non-glycoside, non-catecholamine have also been developed enthusiasm continues to introduce newer novel modes action both acute chronic failure. The background this increasing interest developing is based on fact that potential correct one important functional abnormality, is, reduced contractile function frequently initiates Although principle goal enhance function, it needs be realized relative potencies various not similar understanding mechanism these their hemodynamic has direct relevance patients