Brain structure and aging in chronic temporal lobe epilepsy

摘要: SUMMARY Purpose: To characterize differences in brain structure and their patterns of age-related change individuals with chronic childhood/adolescent onset temporal lobe epilepsy compared healthy controls. Methods: Subjects included participants (n = 55) mean controls 53), age 14–60 years. Brain magnetic resonance imaging (MRI) studies (1.5 T) were processed using FreeSurfer to obtain measures lobar thickness, area, volume as well volumes diverse subcortical structures cerebellum. Group explored followed by cross-sectional lifespan modeling a function age. Key Findings: Anatomic abnormalities extensive including distributed (hippocampus, thalamus, caudate, pallidum), cerebellar gray white matter, total cerebral matter; cortical matter or (medial, lateral) extratemporal lobes (frontal, parietal). Increasing chronologic was associated progressive changes cortical, subcortical, regions for both Age-accelerated seen selected areas (third lateral ventricles), largely comparable across other interest. Significance: Extensive are present implicating significant neurodevelopmental impact on structure. With increasing age, the occurring appear proceed age-appropriate fashion controls, primary exception being age-accelerated ventricular expansion (lateral third ventricles). These cumulative structural represent anatomic burden persons epilepsy, consequences which remain be determined they progress into elder