Proteogenomic examination of esophageal squamous cell carcinoma (ESCC): new lines of inquiry.

摘要: Introduction: Esophageal squamous cell carcinoma (ESCC), a histopathologic subtype of esophageal cancer is major cause cancer-related morbidity and mortality worldwide. This primarily because patients are diagnosed at an advanced stage by the time symptoms appear. The genomics mass spectrometry-based proteomics continue to provide important leads toward biomarker discovery for ESCC. However, such yet be translated into clinical utilities. Areas covered: We gathered information pertaining proteogenomics efforts in ESCC from literature search until 2020. An overview omics approaches discover candidate biomarkers were highlighted. present summary recent investigations alterations level gene protein expression observed biological samples including body fluids, tissue/biopsy vitro-based models. Expert opinion: A large number protein-based therapeutic targets being used therapy. Several candidates developed as diagnostics prognostics management cancers. High-resolution proteomic proteogenomic offer efficient way identify additional diagnosis, monitoring disease progression, prediction response chemo radiotherapy. Some these can also targets.