Study of neurotrophism in normal/dystrophic parabiotic mice.
作者： Akitsugu Saito , Peter K. Law , Sidney Fleischer
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摘要: The trophic influences of nerve and muscle on one another were studied in normal dystrophic littermates C57BL/6J dy2J mice parabiosed at 20 to 23 days after birth. Each parabiont had a soleus cross-reinnervated by tibial its partner. Ultrastructural abnormalities endplate quantified compared 6 7 months postoperatively. degenerated despite reinnervation muscle. did not prevent the from degenerating, induced degenerative changes reinnervated Normal retard genetically programmed degeneration muscle, however, appear cause terminals degenerate. We conclude that both cells express characteristics muscular dystrophy. Muscle fibers few motor units further suffer abnormal neurotrophic influence because neurons. Myotrophic was observed.
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